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Issue 9, 2012
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Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol

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Abstract

Amphiphilic polymers have been synthesised by controlled free radical polymerisation techniques. These polymers self-assemble into well-defined vesicles in aqueous conditions, enabling encapsulation of a model hydrophilic molecule. The polymeric vesicles show high stability against a range of aqueous conditions with marginal release of cargo, even in the presence of known cell-membrane disruptive polymers such as branched poly(ethylene imine) (b-PEI). This stability allows for inversion of the surface charge of the polymeric vesicles by a simple coating protocol leading to an enhanced uptake by mammalian cells.

Graphical abstract: Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol

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Supplementary files

Article information


Submitted
18 May 2012
Accepted
21 Jun 2012
First published
22 Jun 2012

This article is Open Access

Polym. Chem., 2012,3, 2596-2604
Article type
Paper

Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol

G. Yaşayan, M. Redhead, J. P. Magnusson, S. G. Spain, S. Allen, M. Davies, C. Alexander and F. Fernández-Trillo, Polym. Chem., 2012, 3, 2596
DOI: 10.1039/C2PY20352A

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