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Issue 10, 2012
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In situ formation of crosslinked core–corona polymeric nanoparticles from a novel hyperbranched core

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Abstract

A facile approach for the preparation of well-controlled crosslinked core–corona (CCC) nanoparticles is described. Firstly, a core containing multiple initiating sites was generated by deactivation enhanced atom transfer radical homopolymerisation (DE-ATRP) of divinylbenzene (DVB). Then, the multiple halide initiating sites on this hyperbranched polyDVB core were used to initiate linear chains of methyl methacrylate (MMA) via ATRP. During the second step, the pendant vinyl groups within the core were consumed, leading to generation of a crosslinked nanogel core within the final polymer structures isolated, whilst linear arms (corona) were simultaneously growing from the periphery. The structure of the resulting CCC nanoparticles was confirmed using 1H NMR spectroscopy, gel permeation chromatography equipped with MALLS (GPC-MALLS), dynamic light scattering (DLS) and atomic force microscopy (AFM).

Graphical abstract: In situ formation of crosslinked core–corona polymeric nanoparticles from a novel hyperbranched core

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Supplementary files

Article information


Submitted
20 Apr 2012
Accepted
06 Jul 2012
First published
09 Jul 2012

Polym. Chem., 2012,3, 2807-2814
Article type
Paper

In situ formation of crosslinked core–corona polymeric nanoparticles from a novel hyperbranched core

Y. Zheng, K. J. Thurecht, X. Chen, C. J. Roberts, D. J. Irvine, S. M. Howdle and W. Wang, Polym. Chem., 2012, 3, 2807
DOI: 10.1039/C2PY20247F

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