Issue 4, 2012

Terminal functional glycopolymersvia a combination of catalytic chain transfer polymerisation (CCTP) followed by three consecutive click reactions

Abstract

The combination of catalytic chain transfer polymerisation (CCTP) with both thiol-ene and copper catalysed alkyne azide coupling (CuAAC) click chemistry has been employed to give a new route to functional glycopolymers for applications in bioconjugation and biological targeting. Ring opening of poly(glycidyl methacrylate) with sodium azide and subsequent reaction with alkyne functional carbohydrates, as prepared by Fischer glycosylation, has been exploited. This combination of a range of efficient chemistry gives a route to multi gram quantities of glycopolymers avoiding the need for living radical polymerisation chemistry.

Graphical abstract: Terminal functional glycopolymers via a combination of catalytic chain transfer polymerisation (CCTP) followed by three consecutive click reactions

Supplementary files

Article information

Article type
Paper
Submitted
10 Jan 2012
Accepted
26 Jan 2012
First published
03 Feb 2012

Polym. Chem., 2012,3, 1016-1023

Terminal functional glycopolymers via a combination of catalytic chain transfer polymerisation (CCTP) followed by three consecutive click reactions

Q. Zhang, S. Slavin, M. W. Jones, A. J. Haddleton and D. M. Haddleton, Polym. Chem., 2012, 3, 1016 DOI: 10.1039/C2PY20013A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements