Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 2, 2012
Previous Article Next Article

A fluorescently labeled, hyperbranched polymer synthesized from DE-ATRP for the detection of DNA hybridization

Author affiliations

Abstract

The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently been found to be significantly affected in cancer patients, they offer a means of early stage detection of cancer. Towards the goal of creating a novel method of DNA hybridization detection, we report the detection of specific sequences of small oligonucleotides in a model experiment carried out in serum. The results shown here display the versatility of the DE-ATRP method in synthesizing a specific polymer structure capable of changing its physical properties in the presence of double stranded DNA. The polymer was labeled and used to detect single-stranded DNA in serum successfully.

Graphical abstract: A fluorescently labeled, hyperbranched polymer synthesized from DE-ATRP for the detection of DNA hybridization

Back to tab navigation

Supplementary files

Article information


Submitted
02 Nov 2011
Accepted
05 Dec 2011
First published
19 Dec 2011

Polym. Chem., 2012,3, 332-334
Article type
Communication

A fluorescently labeled, hyperbranched polymer synthesized from DE-ATRP for the detection of DNA hybridization

A. Aied, B. Glynn, H. Cao, Y. Zheng, H. Tai, A. Pandit and W. Wang, Polym. Chem., 2012, 3, 332
DOI: 10.1039/C2PY00516F

Social activity

Search articles by author

Spotlight

Advertisements