Issue 2, 2012
From the journal:

Polymer Chemistry

In situ monitoring of enzyme-catalyzed (co)polymerizations by Raman spectroscopy†‡

Matthew T. Hunley,a   Atul S. Bhangale,ab   Santanu Kundu,a   Peter M. Johnson,a   Michael S. Waters,a   Richard A. Gross*b  and  Kathryn L. Beers*a  

* Corresponding authors

a Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD, USA
E-mail: beers@nist.gov
Fax: +1 (301) 975-4924
Tel: +1 (301) 975-2113

b Polytechnic Institute of NYU, Brooklyn, NY, USA
E-mail: rgross@poly.edu
Tel: +1 (718) 260-3024

Abstract

In situ, fiber optic-based Raman spectroscopy provided real time monitoring of enzyme-catalyzed ring-opening homo- and copolymerizations of ε-caprolactone (ε-CL) and δ-valerolactone (δ-VL). A custom designed reactor equipped with in situ fiber optic probe was used to measure monomer conversion as a function of time. The results from the in situ technique were in good agreement with those determined by offline 1H NMR analysis. Monomer reactivity ratios for the lipase-catalyzed copolymerization of ε-CL and δ-VL were estimated using the Kelen-Tudos method as rε-CL = 0.38 and rδ-VL = 0.29.

Graphical abstract: In situ monitoring of enzyme-catalyzed (co)polymerizations by Raman spectroscopy

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Article information

DOI
https://doi.org/10.1039/C1PY00447F
Article type
Communication
Submitted
29 Sep 2011
Accepted
10 Nov 2011
First published
30 Nov 2011

Polym. Chem., 2012,3, 314-318

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In situ monitoring of enzyme-catalyzed (co)polymerizations by Raman spectroscopy

M. T. Hunley, A. S. Bhangale, S. Kundu, P. M. Johnson, M. S. Waters, R. A. Gross and K. L. Beers, Polym. Chem., 2012, 3, 314 DOI: 10.1039/C1PY00447F

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