Jump to main content
Jump to site search

Issue 3, 2012
Previous Article Next Article

Bioinspired dual self-folding of single polymer chains via reversible hydrogen bonding

Author affiliations

Abstract

With the long term aim of preparing synthetic macromolecules that mimic the folding actions of natural biomacromolecules, a single synthetic polymer chain containing two distinct and orthogonal hydrogen bonding recognition motifs has been synthesized using an atom transfer radical polymerization (ATRP) and orthogonal ligation strategy. The hydrogen bonding recognition units, based on both three-point thymine (Thy)–diaminopyridine (DAP) and six-point cyanuric acid (CA)–Hamilton wedge (HW) interactions, induced—at low concentrations—a single chain self-folding process. The self-assembly process was monitored—initially between small molecule models—by proton nuclear magnetic resonance (1H NMR) spectroscopy, revealing full orthogonality of the two recognition pairs, HW–CA and Thy–DAP. Dynamic as well as static light scattering (DLS and SLS) analyses of the macromolecular self-assembly systems provide unambiguous evidence for the hydrogen-bonding interactions between both the Thy–DAP and CA–HW units leading to well-defined dual point single chain self-folding, indicating that more complex single chain self-assemblies based on synthetic polymers should be able to mimic—on a simplified level—the folding actions of natural biomacromolecules. The reversibility of the self-folding action depends on temperature as confirmed via1H-NMR spectroscopy in [D2]tetrachloroethane.

Graphical abstract: Bioinspired dual self-folding of single polymer chains via reversible hydrogen bonding

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Sep 2011, accepted on 09 Oct 2011 and first published on 11 Nov 2011


Article type: Paper
DOI: 10.1039/C1PY00392E
Citation: Polym. Chem., 2012,3, 640-651
  •   Request permissions

    Bioinspired dual self-folding of single polymer chains via reversible hydrogen bonding

    O. Altintas, E. Lejeune, P. Gerstel and C. Barner-Kowollik, Polym. Chem., 2012, 3, 640
    DOI: 10.1039/C1PY00392E

Search articles by author

Spotlight

Advertisements