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Issue 12, 2012
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Vitamin D and drug-metabolising enzymes

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Abstract

Experimental studies on the molecular regulation of human drug metabolism have revealed that vitamin D up-regulates transcription of several key enzymes, such as CYP3A4, through the vitamin D receptor pathway in intestinal and hepatic cells. Recent data suggest that this results in seasonal changes with higher clearance of orally administered drugs during periods with high UV-B radiation and vitamin D levels. Taken together, vitamin D status might contribute to inter- and intraindividual differences in drug metabolism, but the therapeutic impact of these findings remains to be established.

Graphical abstract: Vitamin D and drug-metabolising enzymes

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Article information


Submitted
16 Jun 2012
Accepted
03 Aug 2012
First published
08 Aug 2012

Photochem. Photobiol. Sci., 2012,11, 1797-1801
Article type
Perspective

Vitamin D and drug-metabolising enzymes

J. D. Lindh, L. Björkhem-Bergman and E. Eliasson, Photochem. Photobiol. Sci., 2012, 11, 1797
DOI: 10.1039/C2PP25194A

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