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Issue 10, 2012
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Studies on photodegradation of levomepromazine and olanzapine under simulated environmental conditions

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Abstract

The present study discusses the influence of sunlight on the photostability of levomepromazine (LV) and olanzapine (OLA) hydrochlorides in river water. Four samples of water from different rivers were used in the research. In their course, it turned out that levomepromazine easily underwent photooxidation under simulated environmental conditions, resulting in the generation of its sulphoxide. Olanzapine, on the other hand, appeared to be more resistant to sunlight, as its photodecomposition proceeded slowly, and only one product of its decomposition was detected spectrophotometrically during the process. The photodegradation was analyzed in detail using principal component analysis (PCA) and multivariate curve resolution alternating least squares (MCR-ALS) chemometric methods, and the outcomes verified by HPLC and GC-MS analysis. It can be stated that the rates of the observed processes heavily depended on the chemical composition of the fresh water used in the experiments.

Graphical abstract: Studies on photodegradation of levomepromazine and olanzapine under simulated environmental conditions

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Publication details

The article was received on 21 Sep 2011, accepted on 23 Jul 2012 and first published on 24 Jul 2012


Article type: Paper
DOI: 10.1039/C2PP25068C
Photochem. Photobiol. Sci., 2012,11, 1575-1584

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    Studies on photodegradation of levomepromazine and olanzapine under simulated environmental conditions

    J. Karpińska, A. Sokół, A. Bernatowicz, A. Szulęcka and U. Kotowska, Photochem. Photobiol. Sci., 2012, 11, 1575
    DOI: 10.1039/C2PP25068C

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