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Issue 42, 2012
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Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures

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Abstract

The ability of self-assembling multivalent DNA-binding dendrons to interact with biological targets is modified by co-assembly with two novel low-molecular-weight cholesterol-functionalised PEG units, one based on triethylene glycol (Chol-PEG-3) and one on an octaethylene glycol (Chol-PEG-8). The addition of either PEG lipid affected the co-assembled nanostructure surface charge and size in different ways depending on the structure of the self-assembling DNA-binding dendron. Co-assembly with Chol-PEG-8 enhanced DNA binding, while Chol-PEG-3 inhibited it. Insertion of Chol-PEG-8 into the aggregates modified their ability to cross a model mucus layer, the details of which can be understood in terms of a balance between the mucoadhesivity due to the surface charge of the nanoscale aggregates and that due to the PEG groups. This study demonstrates that the interaction of nanoscale assemblies with biological systems depends on a number of different factors in a sometimes unpredictable way. Given how simply multiple building blocks can be combined by self-assembly, we conclude that self-assembled multivalent systems have great potential for optimisation to maximise their biological and clinical activity.

Graphical abstract: Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures

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Publication details

The article was received on 10 Aug 2012, accepted on 14 Sep 2012 and first published on 03 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26584B
Org. Biomol. Chem., 2012,10, 8403-8409

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    Effects of a PEG additive on the biomolecular interactions of self-assembled dendron nanostructures

    A. Barnard, M. Calderon, A. Tschiche, R. Haag and D. K. Smith, Org. Biomol. Chem., 2012, 10, 8403
    DOI: 10.1039/C2OB26584B

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