Issue 47, 2012
From the journal:

Organic & Biomolecular Chemistry

Effective regioselective protection of amino groups of lysine achieved by a supramolecular enzyme-mimic approach†

Jie Su,a   Xiang Sheng,a   Shangyang Li,a   Tao Sun,a   Guangcun Liub  and  Aiyou Hao*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China
E-mail: haoay@sdu.edu.cn
Fax: +86-531-88564464
Tel: +86-531-88363306

b Qianfoshan Hospital Affiliated to Shandong University, Jinan 250018, P. R. China

Abstract

An enzymic method to protect selected amino group of lysine has been reported. This reaction proceeds smoothly under room temperature with high regioselectivity (up to 99%) and high yields (up to 90%). This work will pave the way for simple and selective protection of amino group of lysine in industry.

Graphical abstract: Effective regioselective protection of amino groups of lysine achieved by a supramolecular enzyme-mimic approach

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Article information

DOI
https://doi.org/10.1039/C2OB27021H
Article type
Communication
Submitted
27 Aug 2012
Accepted
23 Oct 2012
First published
24 Oct 2012

Org. Biomol. Chem., 2012,10, 9319-9324

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Effective regioselective protection of amino groups of lysine achieved by a supramolecular enzyme-mimic approach

J. Su, X. Sheng, S. Li, T. Sun, G. Liu and A. Hao, Org. Biomol. Chem., 2012, 10, 9319 DOI: 10.1039/C2OB27021H

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