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Issue 48, 2012
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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

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Abstract

The synthesis of a series of carbohydrate–nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

Graphical abstract: Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

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Article information


Submitted
09 Aug 2012
Accepted
24 Oct 2012
First published
30 Oct 2012

Org. Biomol. Chem., 2012,10, 9601-9619
Article type
Paper

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

R. M. Deranieh, M. L. Greenberg, Pierre-B. Le Calvez, M. C. Mooney and M. E. Migaud, Org. Biomol. Chem., 2012, 10, 9601
DOI: 10.1039/C2OB26577J

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