Issue 47, 2012
From the journal:

Organic & Biomolecular Chemistry

Direct synthesis of sensitive selenocysteinepeptides by the Ugi reaction†

Muhammad Abbasab  and  Ludger A. Wessjohann*a  

* Corresponding authors

a Leibniz-Institut für Pflanzenbiochemie, Weinberg 3, D-06120 Halle (Saale), Germany
E-mail: wessjohann@ipb-halle.de
Fax: +49 345 5582 1309
Tel: +49 345 5582 1301

b Chair of Advanced Proteomics and Cytomics Research, Faculty of Science, Department of Zoology, King Saud University, P.O. Box 2455, 11415 Riyadh, Saudi Arabia

Abstract

Ammonia and selenoaldehydes are both problematic components in Ugi reactions. Here we report the efficient direct multicomponent synthesis of sensitive selenocysteine peptides without the use of convertible (protected) primary amines, including suitable deprotection protocols for selenols.

Graphical abstract: Direct synthesis of sensitive selenocysteine peptides by the Ugi reaction

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Article information

DOI
https://doi.org/10.1039/C2OB26552D
Article type
Communication
Submitted
06 Aug 2012
Accepted
16 Oct 2012
First published
17 Oct 2012

Org. Biomol. Chem., 2012,10, 9330-9333

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Direct synthesis of sensitive selenocysteine peptides by the Ugi reaction

M. Abbas and L. A. Wessjohann, Org. Biomol. Chem., 2012, 10, 9330 DOI: 10.1039/C2OB26552D

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