Issue 32, 2012
From the journal:

Organic & Biomolecular Chemistry

2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature†

Valeria Azzarito,ab   Panchami Prabhakaran,ab   Alice I. Bartlett,ab   Natasha S. Murphy,ab   Michaele J. Hardie,a   Colin A. Kilner,a   Thomas A. Edwards,bc   Stuart L. Warrinerab  and  Andrew J. Wilson*ab  

* Corresponding authors

a School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, United Kingdom
E-mail: A.J.Wilson@leeds.ac.uk
Fax: +44 (0)113 3436565
Tel: +44 (0)113 3431409

b Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, United Kingdom

c Institute of Molecular and Cellular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, United Kingdom

Abstract

The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.

Graphical abstract: 2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

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Article information

DOI
https://doi.org/10.1039/C2OB26262B
Article type
Communication
Submitted
16 May 2012
Accepted
03 Jul 2012
First published
04 Jul 2012

Org. Biomol. Chem., 2012,10, 6469-6472

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2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

V. Azzarito, P. Prabhakaran, A. I. Bartlett, N. S. Murphy, M. J. Hardie, C. A. Kilner, T. A. Edwards, S. L. Warriner and A. J. Wilson, Org. Biomol. Chem., 2012, 10, 6469 DOI: 10.1039/C2OB26262B

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