Total synthesis of the proposed structure of cyclic hexadepsipeptide veraguamide A

Abstract

We have developed a practical method to assemble the proposed structure of natural product veraguamide A (1) by first preparing the three key fragments followed by optimization of the macrocyclization site. Although the synthetic product gave similar optical rotation to that reported for natural product, significant differences in the ¹H and ¹³C NMR spectra were observed, especially the proton and carbon signals in the two N-MeVal moieties.