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Issue 34, 2012
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Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures

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Abstract

A rapid and efficient protocol to afford the title compound 2-[18F]-fluoro-2,2-difluoroethyl tosylate ([18F]7b) is described. Starting from [18F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([18F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.

Graphical abstract: Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures

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Article information


Submitted
26 Apr 2012
Accepted
27 Jun 2012
First published
28 Jun 2012

Org. Biomol. Chem., 2012,10, 6980-6986
Article type
Paper

Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures

P. J. Riss, V. Ferrari, L. Brichard, P. Burke, R. Smith and F. I. Aigbirhio, Org. Biomol. Chem., 2012, 10, 6980
DOI: 10.1039/C2OB25802A

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