Issue 24, 2012
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed synthesis of 2-amino ketones from propargylic carbonates and secondary amines†

Sandro Cacchi,*a   Giancarlo Fabrizi,a   Eleonora Filisti,a   Antonella Goggiamani,a   Antonia Iazzettia  and  Loredana Mauroneb  

* Corresponding authors

a Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, Rome, Italy
E-mail: sandro.cacchi@uniroma1.it
Fax: +39 (06) 4991-2789
Tel: +39 (06) 4991-2795

b Dipartimento A.B.A.C., Università degli Studi della Tuscia e Consorzio Universitario “La Chimica per l'Ambiente”, Via S. Camillo De Lellis, 01100 Viterbo, Italy

Abstract

A novel palladium-catalyzed approach to 2-amino ketones from arylpropargylic carbonates bearing neutral, electron-rich, and electron-poor aromatic rings and cyclic secondary amines containing useful functional groups such as cyano, chloro, and bromo substituents has been developed.

Graphical abstract: Palladium-catalyzed synthesis of 2-amino ketones from propargylic carbonates and secondary amines

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Article information

DOI
https://doi.org/10.1039/C2OB25670C
Article type
Communication
Submitted
04 Apr 2012
Accepted
10 May 2012
First published
10 May 2012

Org. Biomol. Chem., 2012,10, 4699-4703

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Palladium-catalyzed synthesis of 2-amino ketones from propargylic carbonates and secondary amines

S. Cacchi, G. Fabrizi, E. Filisti, A. Goggiamani, A. Iazzetti and L. Maurone, Org. Biomol. Chem., 2012, 10, 4699 DOI: 10.1039/C2OB25670C

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