Issue 23, 2012
From the journal:

Organic & Biomolecular Chemistry

Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones†

Shaoxia Lin,a   Ying Wei,a   Fushun Liang,*a   Baozhong Zhao,a   Yanling Liub  and  Pengjun Liu*b  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, Changchun 130024, China
E-mail: liangfs112@nenu.edu.cn
Fax: (+86) 431-85099759

b College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China
E-mail: liupj12@126.com

Abstract

A highly efficient multi-component anion relay cascade reaction based on 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile has been developed, which provides strategically novel and atom-economic access to biologically important biscyanoethylated furo[3,2-c]pyridinones. In this one-pot transformation, up to five bonds (one C–N, one C–O and three C–C bonds) were constructed.

Graphical abstract: Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones

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Article information

DOI
https://doi.org/10.1039/C2OB25550B
Article type
Paper
Submitted
14 Mar 2012
Accepted
16 Apr 2012
First published
17 Apr 2012

Org. Biomol. Chem., 2012,10, 4571-4576

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Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones

S. Lin, Y. Wei, F. Liang, B. Zhao, Y. Liu and P. Liu, Org. Biomol. Chem., 2012, 10, 4571 DOI: 10.1039/C2OB25550B

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