Issue 18, 2012
From the journal:

Organic & Biomolecular Chemistry

Nickel-catalyzed C–H direct amination of benzoxazoles with secondary amines†

Yaming Li,*a   Jin Liu,a   Yusheng Xie,a   Rong Zhang,a   Kun Jin,a   Xiuna Wanga  and  Chunying Duan*a  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P.R. China
E-mail: ymli@dlut.edu.cn

Abstract

In this article, a facile, efficient and practical method for Ni-catalyzed direct C–H amination of benzoxazole with secondary amines has been developed. This procedure requires Ni(OAc)2·4H2O as catalyst, TBHP as oxidant and acid as the additive. A variety of substituted benzoxazol-2-amines were synthesized in moderate to good yields.

Graphical abstract: Nickel-catalyzed C–H direct amination of benzoxazoles with secondary amines

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Article information

DOI
https://doi.org/10.1039/C2OB25425E
Article type
Paper
Submitted
27 Feb 2012
Accepted
11 Mar 2012
First published
15 Mar 2012

Org. Biomol. Chem., 2012,10, 3715-3720

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Nickel-catalyzed C–H direct amination of benzoxazoles with secondary amines

Y. Li, J. Liu, Y. Xie, R. Zhang, K. Jin, X. Wang and C. Duan, Org. Biomol. Chem., 2012, 10, 3715 DOI: 10.1039/C2OB25425E

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