Issue 19, 2012

Domino cyclization–alkylation protocol for the synthesis of 2,3-functionalized indoles from o-alkynylanilines and allylic alcohols

Abstract

A practical and efficient protocol for the one-pot synthesis of 2,3-substituted indoles was developed via a palladacycle catalyzed domino cyclization–alkylation reaction involving 2-alkynylanilines and allylic alcohols under mild conditions without any additives.

Graphical abstract: Domino cyclization–alkylation protocol for the synthesis of 2,3-functionalized indoles from o-alkynylanilines and allylic alcohols

Supplementary files

Article information

Article type
Paper
Submitted
22 Feb 2012
Accepted
12 Mar 2012
First published
15 Mar 2012

Org. Biomol. Chem., 2012,10, 3875-3881

Domino cyclization–alkylation protocol for the synthesis of 2,3-functionalized indoles from o-alkynylanilines and allylic alcohols

C. Xu, V. K. Murugan and S. A. Pullarkat, Org. Biomol. Chem., 2012, 10, 3875 DOI: 10.1039/C2OB25379H

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