A mechanism-based fluorescent probe for labeling O6-methylguanine-DNA methyltransferase in live cells

Xin Li; Shijing Qian; Lin Zheng; Bo Yang; Qiaojun He; Yongzhou Hu

doi:10.1039/C2OB25231G

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A mechanism-based fluorescent probe for labelingO⁶-methylguanine-DNA methyltransferase in live cells†

Xin Li,^a Shijing Qian,^b Lin Zheng,^b Bo Yang,^b Qiaojun He^b and Yongzhou Hu*^a

Author affiliations

* Corresponding authors

^a ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
E-mail: huyz@zju.edu.cn
Fax: +086-571-88208460

^b Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, China

Abstract

A mechanism-based small molecular fluorescent probe has been developed to label active O⁶-methylguanine-DNA methyltransferase in live cells.

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Article information

DOI: https://doi.org/10.1039/C2OB25231G
Article type: Communication
Submitted: 31 Jan 2012
Accepted: 01 Mar 2012
First published: 06 Mar 2012

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Org. Biomol. Chem., 2012,10, 3189-3191

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A mechanism-based fluorescent probe for labeling O⁶-methylguanine-DNA methyltransferase in live cells

X. Li, S. Qian, L. Zheng, B. Yang, Q. He and Y. Hu, Org. Biomol. Chem., 2012, 10, 3189 DOI: 10.1039/C2OB25231G

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Organic & Biomolecular Chemistry