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Issue 27, 2012
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Strategies for the enantioselective synthesis of spirooxindoles

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Oxindoles and spirooxindoles are important synthetic targets that are often considered to be prevalidated with respect to their biological activity and applications for pharmaceutical lead discovery. This review features efficient strategies for the enantioselective synthesis of spirocyclic oxindoles, focusing on reports in 2010 and 2011. Although enantioselective synthesis remains an ongoing challenge, exciting recent advances in this area feature spirooxindoles with greater complexity, up to eight stereogenic centers, more practical synthetic methods, and new catalytic activation strategies. Developments in catalyst systems and reaction conditions have shown that many reactions can be optimized to control selectivity and provide access to isomeric products, which are important for biological testing. This review is organized based on two primary disconnection strategies, and then further subdivided into the type and ring size of the spirocycle that is generated. Strategies are also compared for the synthesis of non-spirocyclic 3,3′-disubstituted oxindoles.

Graphical abstract: Strategies for the enantioselective synthesis of spirooxindoles

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Publication details

The article was received on 25 Jan 2012, accepted on 11 Apr 2012 and first published on 16 Apr 2012

Article type: Perspective
DOI: 10.1039/C2OB25184A
Org. Biomol. Chem., 2012,10, 5165-5181

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    Strategies for the enantioselective synthesis of spirooxindoles

    N. R. Ball-Jones, J. J. Badillo and A. K. Franz, Org. Biomol. Chem., 2012, 10, 5165
    DOI: 10.1039/C2OB25184A

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