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Issue 17, 2012
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Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

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Abstract

A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), “PHEEPA” [(2-pyrimidinyl-2-(2-hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. These compounds, which possess on one side a hydroxy function and on the other side a phosphonate group, can be considered either as potential antiviral agents or as transition state analogues of nucleoside phosphorylases such as thymidine phosphorylase.

Graphical abstract: Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

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Article information


Submitted
17 Jan 2012
Accepted
29 Feb 2012
First published
29 Feb 2012

Org. Biomol. Chem., 2012,10, 3448-3454
Article type
Paper

Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

B. Dayde, S. Benzaria, C. Pierra, G. Gosselin, D. Surleraux, J. Volle, J. Pirat and D. Virieux, Org. Biomol. Chem., 2012, 10, 3448
DOI: 10.1039/C2OB25131K

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