Issue 14, 2012
From the journal:

Organic & Biomolecular Chemistry

One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: synthesis of model benzodiazepine(di)ones promoted by microwave irradiation†

Leonardo Ciofi,a   Andrea Trabocchi,*a   Claudia Lalli,b   Gloria Menchia  and  Antonio Guarnaa  

* Corresponding authors

a Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 13, I-50019 Sesto Fiorentino, Florence, Italy
E-mail: andrea.trabocchi@unifi.it
Fax: +39 055 457 3531
Tel: +39 055 457 3507

b Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France

Abstract

The application of sequential Ti-/Cu-catalysis in the model one-pot synthesis of benzodiazepine(di)ones promoted by microwave irradiation demonstrates the expediency of dual catalysis in coupling-cyclization methods useful for diversity-oriented synthesis.

Graphical abstract: One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: synthesis of model benzodiazepine(di)ones promoted by microwave irradiation

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Article information

DOI
https://doi.org/10.1039/C2OB07063D
Article type
Paper
Submitted
09 Dec 2011
Accepted
30 Jan 2012
First published
31 Jan 2012

Org. Biomol. Chem., 2012,10, 2780-2786

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One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: synthesis of model benzodiazepine(di)ones promoted by microwave irradiation

L. Ciofi, A. Trabocchi, C. Lalli, G. Menchi and A. Guarna, Org. Biomol. Chem., 2012, 10, 2780 DOI: 10.1039/C2OB07063D

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