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Issue 13, 2012
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Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin

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Abstract

The synthesis of β-thiolactone and β-lactam analogs of tetrahydrolipstatin is described from a common late-stage β-lactone derivative. These analogs, and a cis-disubstituted β-lactone analog of tetrahydrolipstatin, were screened for activity against porcine pancreatic lipase and for inhibition of cell growth of a panel of four human cancer lines.

Graphical abstract: Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin

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Publication details

The article was received on 23 Nov 2011, accepted on 16 Jan 2012 and first published on 18 Jan 2012


Article type: Paper
DOI: 10.1039/C2OB06976H
Org. Biomol. Chem., 2012,10, 2629-2632

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    Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin

    S. Aubry, G. Aubert, T. Cresteil and D. Crich, Org. Biomol. Chem., 2012, 10, 2629
    DOI: 10.1039/C2OB06976H

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