Issue 14, 2012
From the journal:

Organic & Biomolecular Chemistry

Copper(i) acetate-catalyzed azide–alkynecycloaddition for highly efficient preparation of 1-(pyridin-2-yl)-1,2,3-triazoles†

Qun Zhang,a   Xinyan Wang,*a   Chuanjie Cheng,a   Rui Zhu,a   Nan Liua  and  Yuefei Hu*a  

* Corresponding authors

a Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
E-mail: wangxinyan@mail.tsinghua.edu.cn, yfh@mail.tsinghua.edu.cn
Fax: +86 62771149
Tel: +86 6279 5380

Abstract

A highly efficient copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) of 6-substituted tetrazolo[1,5-a]pyridines was developed for the preparation of 1-(pyridin-2-yl)-1,2,3-triazoles by simply using copper(I) acetate as a catalyst. The in situ formed HOAc played important dual roles and an activation of 2-azidopyridine–copper(I) complex was observed.

Graphical abstract: Copper(i) acetate-catalyzed azide–alkyne cycloaddition for highly efficient preparation of 1-(pyridin-2-yl)-1,2,3-triazoles

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Article information

DOI
https://doi.org/10.1039/C2OB06942C
Article type
Paper
Submitted
18 Nov 2011
Accepted
01 Feb 2012
First published
01 Feb 2012

Org. Biomol. Chem., 2012,10, 2847-2854

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Copper(I) acetate-catalyzed azide–alkyne cycloaddition for highly efficient preparation of 1-(pyridin-2-yl)-1,2,3-triazoles

Q. Zhang, X. Wang, C. Cheng, R. Zhu, N. Liu and Y. Hu, Org. Biomol. Chem., 2012, 10, 2847 DOI: 10.1039/C2OB06942C

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