Issue 11, 2012

Trichlorosilane mediated asymmetric reductions of the C[double bond, length as m-dash]N bond

Abstract

Chiral amines are key components in numerous bioactive molecules. The development of efficient and economical ways to access molecules containing this functional group still remains a challenge at the forefront of synthetic chemistry. Of the methods that do exist, the trichlorosilane mediated organocatalytic reduction of ketimines offers significant potential as an alternative strategy. In this perspective, we wish to highlight the progress made in the past decade in this field and offer a direct quantitative comparison to transition-metal mediated process.

Graphical abstract: Trichlorosilane mediated asymmetric reductions of the C [[double bond, length as m-dash]] N bond

Article information

Article type
Perspective
Submitted
03 Nov 2011
Accepted
21 Dec 2011
First published
22 Dec 2011

Org. Biomol. Chem., 2012,10, 2189-2200

Trichlorosilane mediated asymmetric reductions of the C[double bond, length as m-dash]N bond

S. Jones and C. J. A. Warner, Org. Biomol. Chem., 2012, 10, 2189 DOI: 10.1039/C2OB06854K

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