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Issue 8, 2012

Simple copper/TEMPO catalyzed aerobic dehydrogenation of benzylic amines and anilines

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Abstract

CuBr2 with 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) has been successfully employed for the aerobic oxidation of primary and secondary benzyl amines in aqueous acetonitrile. Such catalytic systems have previously been used extensively in alcohol oxidation reactions. The same catalyst system was also used for oxidative cross-couplings of benzylamines with anilines. The electronic and steric properties of the aniline partner were found to be of crucial importance in determining reactivity or lack thereof. A mechanism for these reactions is proposed based on the data obtained to date. In the absence of benzyl amines, electron-rich anilines were found to undergo dehydrogenative coupling and yields of the resulting azo products could be increased by replacing CuBr2 with CuBr. No ligand (e.g.pyridine) is required for either reaction to proceed and presumably water and acetonitrile solvate the copper-containing intermediates.

Graphical abstract: Simple copper/TEMPO catalyzed aerobic dehydrogenation of benzylic amines and anilines

Supplementary files

Article information


Submitted
02 Oct 2011
Accepted
28 Nov 2011
First published
30 Nov 2011

Org. Biomol. Chem., 2012,10, 1618-1624
Article type
Paper

Simple copper/TEMPO catalyzed aerobic dehydrogenation of benzylic amines and anilines

Z. Hu and F. M. Kerton, Org. Biomol. Chem., 2012, 10, 1618 DOI: 10.1039/C2OB06670J

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