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Issue 4, 2012
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Multicomponent approaches to 8-carboxylnaphthyl-functionalized pyrazolo[3,4-b]pyridine derivatives

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Abstract

A simple and novel protocol for the efficient synthesis of a series of 8-carboxylnaphthyl functionalized pyrazolo[3,4-b]pyridine derivatives was developed through a one-pot, three-component reaction involving acenaphthylene-1,2-dione and 1H-pyrazol-5-amine in acetic acid medium. The reaction represents the first facile conversion of acenaphthenequinone to naphthoic acid via C–C bond cleavage without need for multi-step transformation.

Graphical abstract: Multicomponent approaches to 8-carboxylnaphthyl-functionalized pyrazolo[3,4-b]pyridine derivatives

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Article information


Submitted
23 Sep 2011
Accepted
15 Nov 2011
First published
16 Nov 2011

Org. Biomol. Chem., 2012,10, 724-728
Article type
Communication

Multicomponent approaches to 8-carboxylnaphthyl-functionalized pyrazolo[3,4-b]pyridine derivatives

Y. Hao, X. Xu, T. Chen, L. Zhao and S. Ji, Org. Biomol. Chem., 2012, 10, 724
DOI: 10.1039/C1OB06624B

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