Issue 5, 2012
From the journal:

Organic & Biomolecular Chemistry

Efficient synthetic method for the preparation of allyl- and propargyl-epoxides by allylation and propargylation of α-haloketones with organozinc reagents†

Jie Pan,a   Min Zhanga  and  Songlin Zhang*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry. Chemical Engineering and Materials Science of Soochow University, Suzhou, People's Republic of China
E-mail: zhangsl@suda.edu.cn

Abstract

A simple, efficient, and non-metal catalyzed synthetic method for the preparation of substituted allyl- and propargyl-epoxides by allylation and propargylation of α-halo ketones with organozinc reagents in mild conditions is reported in this paper. The present method complements the existing synthetic methods due to some advantageous properties of the organozinc reagents such as availability, selectivity, operational simplicity and low toxicity.

Graphical abstract: Efficient synthetic method for the preparation of allyl- and propargyl-epoxides by allylation and propargylation of α-haloketones with organozinc reagents

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Article information

DOI
https://doi.org/10.1039/C1OB06071F
Article type
Paper
Submitted
03 Jul 2011
Accepted
02 Nov 2011
First published
03 Nov 2011

Org. Biomol. Chem., 2012,10, 1060-1067

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Efficient synthetic method for the preparation of allyl- and propargyl-epoxides by allylation and propargylation of α-haloketones with organozinc reagents

J. Pan, M. Zhang and S. Zhang, Org. Biomol. Chem., 2012, 10, 1060 DOI: 10.1039/C1OB06071F

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