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Issue 22, 2012

Differential response of macrophages to core–shell Fe3O4@Au nanoparticles and nanostars

Author affiliations

Abstract

Murine RAW 264.7 cells were exposed to spheroidal core–shell Fe3O4@Au nanoparticles (SCS-NPs, ca. 34 nm) or nanostars (NSTs, ca. 100 nm) in the presence of bovine serum albumin, with variable effects observed after macrophagocytosis. Uptake of SCS-NPs caused macrophages to adopt a rounded, amoeboid form, accompanied by an increase in surface detachment. In contrast, the uptake of multibranched NSTs did not induce gross changes in macrophage shape or adhesion, but correlated instead with cell enlargement and signatures of macrophage activation such as TNF-α and ROS. MTT assays indicate a low cytotoxic response to either SCS-NPs or NSTs despite differences in macrophage behavior. These observations show that differences in NP size and shape are sufficient to produce diverse responses in macrophages following uptake.

Graphical abstract: Differential response of macrophages to core–shell Fe3O4@Au nanoparticles and nanostars

Supplementary files

Article information


Submitted
30 Jul 2012
Accepted
19 Sep 2012
First published
21 Sep 2012

Nanoscale, 2012,4, 7143-7148
Article type
Paper

Differential response of macrophages to core–shell Fe3O4@Au nanoparticles and nanostars

W. Xia, H. Song, Q. Wei and A. Wei, Nanoscale, 2012, 4, 7143 DOI: 10.1039/C2NR32070C

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