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Issue 15, 2012
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Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

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Abstract

We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1–42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2–4 GPa.

Graphical abstract: Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

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Publication details

The article was received on 30 Mar 2012, accepted on 09 May 2012 and first published on 11 May 2012


Article type: Communication
DOI: 10.1039/C2NR30768E
Citation: Nanoscale, 2012,4, 4426-4429

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    Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

    J. Adamcik, C. Lara, I. Usov, J. S. Jeong, F. S. Ruggeri, G. Dietler, H. A. Lashuel, I. W. Hamley and R. Mezzenga, Nanoscale, 2012, 4, 4426
    DOI: 10.1039/C2NR30768E

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