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Issue 14, 2012
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Selective determination of dopamine using quantum-sized gold nanoparticles protected with charge selective ligands

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Abstract

We report here the selective determination of dopamine (DA) using quantum-sized gold nanoparticles coated with charge selective ligands. Glutathione protected gold nanoparticles (GS-Au25) were synthesized and immobilized into a sol–gel matrix via thiol linkers. The GS-Au25 modified sol–gel electrode was found to show excellent electrocatalytic activity towards the oxidation of DA but no activity towards the oxidation of ascorbic acid. The role of electrostatic charge in the selective electrocatalytic activity of GS-Au25 was verified by voltammetry of redox markers carrying opposite charges. The pH dependent sensitivity for the determination of DA further confirmed the charge screening effect of GS-Au25. Mechanistic investigation revealed that the selectivity is attained by the selective formation of an electrostatic complex between the negatively charged GS-Au25 and DA cation. The GS-Au25 modified sol–gel electrode also showed excellent selectivity for DA in the presence of an interferent, ascorbic acid.

Graphical abstract: Selective determination of dopamine using quantum-sized gold nanoparticles protected with charge selective ligands

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Supplementary files

Article information


Submitted
28 Feb 2012
Accepted
07 Apr 2012
First published
11 Apr 2012

Nanoscale, 2012,4, 4240-4246
Article type
Paper

Selective determination of dopamine using quantum-sized gold nanoparticles protected with charge selective ligands

K. Kwak, S. S. Kumar and D. Lee, Nanoscale, 2012, 4, 4240
DOI: 10.1039/C2NR30481C

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