Issue 6, 2012
From the journal:

Nanoscale

Enhancement of biological activities of nanostructured hydrophobic drug species†

Qiusen Han,a   Rong Yang,*a   Jingying Li,a   Wei Liang,b   Ying Zhang,a   Mingdong Dong,c   Flemming Besenbacherc  and  Chen Wang*a  

* Corresponding authors

a CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
E-mail: yangr@nanoctr.cn, wangch@nanoctr.cn

b Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

c Interdisciplinary Nanoscience Center, Aarhus University, Denmark

Abstract

We report a study of nanoribbons of quercetin, a phase I clinical trial anticancer drug, and their inhibitory effects on cancer cell proliferation. Novel quercetin nanoribbons have been prepared by atmospheric pressure physical vapor deposition (PVD). The nanostructures have been characterized by optical microscopy, scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy, etc. Significantly enhanced solubility in PBS solution and increased drug release rate have been observed for quercetin nanoribbons in comparison to those of quercetin powder. The observed increase of inhibitory effects of quercetin nanoribbons on 4T1 cancel cell growth is correlated with an improvement in their solubility and drug release behavior.

Graphical abstract: Enhancement of biological activities of nanostructured hydrophobic drug species

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Article information

DOI
https://doi.org/10.1039/C2NR12013E
Article type
Paper
Submitted
16 Dec 2011
Accepted
19 Jan 2012
First published
13 Feb 2012

Nanoscale, 2012,4, 2078-2082

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Enhancement of biological activities of nanostructured hydrophobic drug species

Q. Han, R. Yang, J. Li, W. Liang, Y. Zhang, M. Dong, F. Besenbacher and C. Wang, Nanoscale, 2012, 4, 2078 DOI: 10.1039/C2NR12013E

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