Issue 21, 2012
From the journal:

Nanoscale

Nanomechanical identification of proteins using microcantilever-based chemical sensors

Ping Wang,a   Hao Pei,a   Ying Wan,b   Jiang Li,a   Xinhua Zhu,*b   Yan Su,b   Chunhai Fana  and  Qing Huang*a  

* Corresponding authors

a Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
E-mail: huangqing@sinap.ac.cn
Tel: +86 21 39194129

b School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
E-mail: zhuxinhua@mail.njust.edu.cn

Abstract

We have developed a microcantilever based sensor array which can be functionalized with mercapto-compounds to detect proteins. Linear discriminant analysis (LDA) is used to differentiate the cantilever deflection patterns. It is concluded that more sensors give better separating capacity and the COOH and Si–OCH3 groups are important factors in protein recognition.

Graphical abstract: Nanomechanical identification of proteins using microcantilever-based chemical sensors

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Article information

DOI
https://doi.org/10.1039/C2NR31705B
Article type
Communication
Submitted
03 Jul 2012
Accepted
27 Aug 2012
First published
29 Aug 2012

Nanoscale, 2012,4, 6739-6742

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Nanomechanical identification of proteins using microcantilever-based chemical sensors

P. Wang, H. Pei, Y. Wan, J. Li, X. Zhu, Y. Su, C. Fan and Q. Huang, Nanoscale, 2012, 4, 6739 DOI: 10.1039/C2NR31705B

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