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Issue 19, 2012
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Voltage controlled nano-injection system for single-cell surgery

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Abstract

Manipulation and analysis of single cells is the next frontier in understanding processes that control the function and fate of cells. Herein we describe a single-cell injection platform based on nanopipettes. The system uses scanning microscopy techniques to detect cell surfaces, and voltage pulses to deliver molecules into individual cells. As a proof of concept, we injected adherent mammalian cells with fluorescent dyes.

Graphical abstract: Voltage controlled nano-injection system for single-cell surgery

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Supplementary files

Article information


Submitted
02 Jul 2012
Accepted
23 Jul 2012
First published
31 Jul 2012

Nanoscale, 2012,4, 5843-5846
Article type
Communication

Voltage controlled nano-injection system for single-cell surgery

R. Adam Seger, P. Actis, C. Penfold, M. Maalouf, B. Vilozny and N. Pourmand, Nanoscale, 2012, 4, 5843
DOI: 10.1039/C2NR31700A

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