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Issue 9, 2012
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Correlative light-ion microscopy for biological applications

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Abstract

Here we report a new technique, Correlative Light-Ion Microscopy (CLIM), to correlate SEM-like micrographs with fluorescence images. This technique presents significant advantages over conventional methods in enabling topographical and biochemical information to be correlated with nanoscale resolution without destroying the fluorescence signal. We demonstrate the utility of CLIM for a variety of investigations of cell substrate interactions validating its potential to become a routine procedure in biomedical research.

Graphical abstract: Correlative light-ion microscopy for biological applications

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Supplementary files

Article information


Submitted
23 Feb 2012
Accepted
27 Feb 2012
First published
06 Mar 2012

Nanoscale, 2012,4, 2851-2854
Article type
Communication

Correlative light-ion microscopy for biological applications

S. Bertazzo, T. von Erlach, S. Goldoni, P. L. Çandarlıoğlu and M. M. Stevens, Nanoscale, 2012, 4, 2851
DOI: 10.1039/C2NR30431G

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