Issue 4, 2012
From the journal:

Nanoscale

The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy†

Yuping Shan,‡ac   Jinfeng Huang,‡b   Juanjuan Tan,b   Gui Gao,b   Shuheng Liu,a   Hongda Wang*a  and  Yuxin Chen*b  

* Corresponding authors

a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China
E-mail: hdwang@ciac.jl.cn

b Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, Jilin, P. R. China
E-mail: chen_yuxin@jlu.edu.cn

c Graduate School of Chinese Academy of Sciences, Beijing, P. R. China

Abstract

To determine the effects of biophysical parameters (e.g. charge, hydrophobicity, helicity) of peptides on the mechanism of anticancer activity, we applied a single molecule technique—force spectroscopy based on atomic force microscope (AFM)—to study the interaction force at the single molecule level. The activity of the peptide and analogs against HeLa cells exhibited a strong correlation with the hydrophobicity of peptides. Our results indicated that the action mode between α-helical peptides and cancer cells was largely hydrophobicity-dependent.

Graphical abstract: The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy

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Article information

DOI
https://doi.org/10.1039/C2NR11541G
Article type
Communication
Submitted
19 Oct 2011
Accepted
07 Dec 2011
First published
03 Jan 2012

Nanoscale, 2012,4, 1283-1286

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The study of single anticancer peptides interacting with HeLa cell membranes by single molecule force spectroscopy

Y. Shan, J. Huang, J. Tan, G. Gao, S. Liu, H. Wang and Y. Chen, Nanoscale, 2012, 4, 1283 DOI: 10.1039/C2NR11541G

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