Observation of molecular inhibition and binding structures of amyloid peptides

Chenxuan Wang; Aihua Yang; Xia Li; Denghua Li; Min Zhang; Huiwen Du; Chao Li; Yuanyuan Guo; Xiaobo Mao; Mingdong Dong; Flemming Besenbacher; Yanlian Yang; Chen Wang

doi:10.1039/C2NR11508E

Observation of molecular inhibition and binding structures of amyloid peptides

Chenxuan Wang,^ac Aihua Yang,^a Xia Li,^a Denghua Li,^a Min Zhang,^a Huiwen Du,^a Chao Li,^a Yuanyuan Guo,^a Xiaobo Mao,^a Mingdong Dong,^b Flemming Besenbacher,^b Yanlian Yang*^a and Chen Wang*^a

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* Corresponding authors

^a National Center for Nanoscience and Technology, Beijing, P. R. China
E-mail: yangyl@nanoctr.cn, wangch@nanoctr.cn
Fax: +86-10-62656765
Tel: +86-10-82545561

^b Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, Denmark

^c Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, P. R. China

Abstract

Unveiling interactions between labeling molecules and amyloid fibrils is essential to develop new detection methods for studying amyloid structures under various conditions. This review endeavours to reflect the progress in studying interactions between molecular inhibitors and amyloid peptides using a series of experimental approaches, such as X-ray diffraction, nuclear magnetic resonance, scanning probe microscopy, and electron microscopy. The revealed binding mechanisms of anti-amyloid drugs and target proteins could benefit the rational design of drugs for prevention or treatment of amyloidal diseases.

Nanoscale

Observation of molecular inhibition and binding structures of amyloid peptides

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