Issue 2, 2012
From the journal:

Nanoscale

In situ synthesis of porous silicananoparticles for covalent immobilization of enzymes†

Xiaowei Yang,‡a   Zhengwei Cai,‡a   Zhangmei Ye,a   Sheng Chen,a   Yu Yang,a   Haifang Wang,*a   Yuanfang Liuab  and  Aoneng Cao*a  

* Corresponding authors

a Institute of Nanochemistry and Nanobiology Shanghai University, Shanghai, China
E-mail: ancao@shu.edu.cn, hwang@shu.edu.cn
Fax: +86-21-66135275
Tel: +86-21-66135277-102

b Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China

Abstract

A simple method is used to covalently encapsulate enzymes in silica nanoparticles. The encapsulation is highlighted by the high enzyme loading and porous channels that provide efficient diffusion for small substrate and product molecules while preventing protease degradation.

Graphical abstract: In situ synthesis of porous silica nanoparticles for covalent immobilization of enzymes

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Article information

DOI
https://doi.org/10.1039/C1NR11153A
Article type
Communication
Submitted
23 Aug 2011
Accepted
26 Oct 2011
First published
17 Nov 2011

Nanoscale, 2012,4, 414-416

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In situ synthesis of porous silica nanoparticles for covalent immobilization of enzymes

X. Yang, Z. Cai, Z. Ye, S. Chen, Y. Yang, H. Wang, Y. Liu and A. Cao, Nanoscale, 2012, 4, 414 DOI: 10.1039/C1NR11153A

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