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Issue 10, 2012
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The structures of type I polyketide synthases

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Covering: up to 2012

With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and mechanisms of these enormous molecular factories. This review highlights not only what has been revealed about the structures and activities of each of the domains but also the mysteries that remain to be solved.

Graphical abstract: The structures of type I polyketide synthases

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Publication details

The article was received on 09 Feb 2012 and first published on 03 Aug 2012

Article type: Review Article
DOI: 10.1039/C2NP20019H
Nat. Prod. Rep., 2012,29, 1050-1073

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    The structures of type I polyketide synthases

    A. T. Keatinge-Clay, Nat. Prod. Rep., 2012, 29, 1050
    DOI: 10.1039/C2NP20019H

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