Jump to main content
Jump to site search

Issue 1, 2012
Previous Article Next Article

Sesquiterpene synthases: Passive catalysts or active players?

Author affiliations

Abstract

Covering: up to July 2011

Sesquiterpene synthases catalyse the metal dependent turnover of farnesyl diphosphate to generate a class of natural products characterised by an enormous diversity in structure, stereochemistry, biological function and application. It has been proposed that these enzymes take a passive role in the reactions they catalyse and that they serve mostly as stereochemical templates, within which the reactions take place. Here, recent research into the structure and function of sesquiterpene synthases and the mechanisms of the reactions that they catalyse will be reviewed to suggest that these fascinating enzymes play multifaceted active roles in what are arguably the most complex biosynthetic reactions.

Graphical abstract: Sesquiterpene synthases: Passive catalysts or active players?

Back to tab navigation

Publication details

The article was received on 29 Jul 2011 and first published on 08 Nov 2011


Article type: Review Article
DOI: 10.1039/C1NP00060H
Nat. Prod. Rep., 2012,29, 60-71

  •   Request permissions

    Sesquiterpene synthases: Passive catalysts or active players?

    D. J. Miller and R. K. Allemann, Nat. Prod. Rep., 2012, 29, 60
    DOI: 10.1039/C1NP00060H

Search articles by author

Spotlight

Advertisements