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Issue 9, 2012
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Lasso peptides: structure, function, biosynthesis, and engineering

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Covering: up to May 2012

Lasso peptides are a class of ribosomally-synthesized and posttranslationally-modified natural products with diverse bioactivities. This review describes the structure and function of all known lasso peptides (as of mid-2012) and covers our current knowledge about the biosynthesis of those molecules. The isolation and characterization of lasso peptides are also covered as are bioinformatics strategies for the discovery of new lasso peptides from genomic sequence data. Several studies on the engineering of new or improved function into lasso peptides are highlighted, and unanswered questions in the field are also described.

Graphical abstract: Lasso peptides: structure, function, biosynthesis, and engineering

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Publication details

The article was received on 16 Jun 2012 and first published on 25 Jul 2012

Article type: Review Article
DOI: 10.1039/C2NP20070H
Citation: Nat. Prod. Rep., 2012,29, 996-1006

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    Lasso peptides: structure, function, biosynthesis, and engineering

    M. O. Maksimov, S. J. Pan and A. James Link, Nat. Prod. Rep., 2012, 29, 996
    DOI: 10.1039/C2NP20070H

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