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Issue 10, 2012
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The structural biology of enzymes involved in natural product glycosylation

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Abstract

Covering: up to 2012

The glycosylation of microbial natural products often dramatically influences the biological and/or pharmacological activities of the parental metabolite. Over the past decade, crystal structures of several enzymes involved in the biosynthesis and attachment of novel sugars found appended to natural products have emerged. In many cases, these studies have paved the way to a better understanding of the corresponding enzyme mechanism of action and have served as a starting point for engineering variant enzymes to facilitate to production of differentially-glycosylated natural products. This review specifically summarizes the structural studies of bacterial enzymes involved in biosynthesis of novel sugar nucleotides.

Graphical abstract: The structural biology of enzymes involved in natural product glycosylation

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Publication details

The article was received on 20 Mar 2012 and first published on 12 Jun 2012


Article type: Review Article
DOI: 10.1039/C2NP20039B
Nat. Prod. Rep., 2012,29, 1201-1237

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    The structural biology of enzymes involved in natural product glycosylation

    S. Singh, G. N. Phillips Jr. and J. S. Thorson, Nat. Prod. Rep., 2012, 29, 1201
    DOI: 10.1039/C2NP20039B

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