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Issue 3, 2012
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Natural products as kinase inhibitors

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Covering: up to 2011

Natural products have been widely used to dissect the basic mechanisms of fundamental life science and as clinical therapeutics. Recently, there has been significant interest in discovering new chemical pharmacophores in natural products to fulfil the vast demand for novel kinase inhibitors and address critical unmet medical needs with respect to signal transduction pathways. In this review, we summarize the history of several different classes of natural product-derived kinase inhibitors, discuss their kinome-wide target profiles and examine their structural binding modes based on available 3D X-ray structures. In particular, their origin, target activity, selectivity, scope and potential therapeutic development are highlighted against the backdrop of medicinal chemistry.

Graphical abstract: Natural products as kinase inhibitors

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Publication details

The article was received on 16 Nov 2011 and first published on 10 Jan 2012

Article type: Review Article
DOI: 10.1039/C2NP00097K
Nat. Prod. Rep., 2012,29, 392-403

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    Natural products as kinase inhibitors

    J. Liu, Y. Hu, D. L. Waller, J. Wang and Q. Liu, Nat. Prod. Rep., 2012, 29, 392
    DOI: 10.1039/C2NP00097K

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