Issue 4, 2012
From the journal:

Natural Product Reports

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

Zhao-Li Zhou,†a   Ya-Xi Yang,†b   Jian Ding,a   Yuan-Chao Li*b  and  Ze-Hong Miao*a  

* Corresponding authors

a Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, P.R. China
E-mail: zhmiao@mail.shcnc.ac.cn
Fax: +86-21-50806820
Tel: + 86-21-50806820

b Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, P.R. China
E-mail: ycli@mail.shcnc.ac.cn
Fax: + 86-21-50807288
Tel: + 86-21-50807288

Abstract

Covering: 1972 to 2011

Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure–activity relationships, pharmacology, and clinical development of triptolide in the last forty years.

Graphical abstract: Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C2NP00088A
Article type
Review Article
Submitted
09 Nov 2011
First published
23 Jan 2012

Nat. Prod. Rep., 2012,29, 457-475

Permissions

Request permissions

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

Z. Zhou, Y. Yang, J. Ding, Y. Li and Z. Miao, Nat. Prod. Rep., 2012, 29, 457 DOI: 10.1039/C2NP00088A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements