Tuning enantioselectivity for crystallization-induced asymmetric synthesis of a conglomerating oxo-rhenium(v) complex

Abstract

Crystallization-induced asymmetric synthesis of conglomerates could be an innovative and powerful tool in the enantioselective preparation of compounds without any chiral auxiliaries but with requirement of appropriate adjustment of the reaction conditions. It is demonstrated that synthesis of the conglomerating chiral oxo-rhenium(V) complex cis-[ReOCl₂(P∼O)py] (P∼O = (OCMe₂CMe₂O)–POCMe₂CMe₂O⁽¹⁻⁾), yielding practically racemate can be made extremely enantioselective by fine-tuning the reaction conditions.