Biotransformation of BMOV in the presence of blood serum proteins

Daniele Sanna; Linda Bíró; Péter Buglyó; Giovanni Micera; Eugenio Garribba

doi:10.1039/C1MT00161B

Biotransformation of BMOV in the presence of blood serum proteins†

Daniele Sanna,^a Linda Bíró,^b Péter Buglyó,^b Giovanni Micera^c and Eugenio Garribba*^c

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* Corresponding authors

^a Istituto CNR di Chimica Biomolecolare, Trav. La Crucca 3, I-07040 Sassari, Italy

^b Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4010 Debrecen, Hungary

^c Dipartimento di Chimica and Centro Interdisciplinare per lo Sviluppo della Ricerca Biotecnologica e per lo Studio della Biodiversità della Sardegna, Università di Sassari, Via Vienna 2, I-07100 Sassari, Italy
E-mail: garribba@uniss.it
Fax: +39 079 212069
Tel: +39 079 229487

Abstract

The interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)₂(hTf), cis-VO(ma)₂(HSA) and cis-VO(ma)₂(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.

Metallomics

Biotransformation of BMOV in the presence of blood serum proteins†

Abstract

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