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Issue 9, 2012
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The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

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Abstract

Aqueous solubility, protein binding and CYP450 inhibition data for compounds containing a variety of heteroaromatic and heteroaliphatic rings were analysed and compared to determine which ring types fared best and worst in these developability screens. The results suggest that certain heterorings are generally more developable than others: how this information may be used and some caveats to be borne in mind are discussed.

Graphical abstract: The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

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Article information


Submitted
02 May 2012
Accepted
12 Jun 2012
First published
18 Jun 2012

Med. Chem. Commun., 2012,3, 1062-1069
Article type
Concise Article

The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?

T. J. Ritchie, S. J. F. Macdonald, S. Peace, S. D. Pickett and C. N. Luscombe, Med. Chem. Commun., 2012, 3, 1062
DOI: 10.1039/C2MD20111A

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