Issue 8, 2012
From the journal:

MedChemComm

Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans†‡

James F. Sanchez,a   Ruth Entwistle,b   David Corcoran,a   Berl R. Oakleyb  and  Clay C. C. Wang*ac  

* Corresponding authors

a Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90089, USA
E-mail: clayw@usc.edu

b Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave., Lawrence, KS 66045, USA

c Department of Chemistry, University of Southern California, College of Letters, Arts, and Sciences, Los Angeles, California 90089, USA

Abstract

We recently demonstrated that the phytotoxin cichorine is produced by Aspergillus nidulans. Through a set of targeted deletions, we have found a cluster of seven genes that are required for its biosynthesis. Two of the deletions yielded molecules that give information about the biosynthesis of this metabolite.

Graphical abstract: Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans

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Article information

DOI
https://doi.org/10.1039/C2MD20055D
Article type
Concise Article
Submitted
22 Feb 2012
Accepted
12 Apr 2012
First published
17 Apr 2012

Med. Chem. Commun., 2012,3, 997-1002

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Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans

J. F. Sanchez, R. Entwistle, D. Corcoran, B. R. Oakley and C. C. C. Wang, Med. Chem. Commun., 2012, 3, 997 DOI: 10.1039/C2MD20055D

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