Issue 11, 2012
From the journal:

MedChemComm

Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities†

Jian-Feng Ge,*a   Qian-Qian Zhang,a   Jian-Mei Lu,*a   Marcel Kaiser,b   Sergio Wittlin,b   Reto Brunb  and  Masataka Ihara*c  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou 215123, China
E-mail: ge_jianfeng@hotmail.com, lujm@suda.edu.cn
Fax: +68-512-65880367
Tel: +86-512-58884717

b Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland
E-mail: marcel.kaiser@unibas.ch
Fax: +41-61-284-82 05
Tel: +41-61-284-82 05

c Drug Discovery Science Research Centre, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
E-mail: m-ihara@hoshi.ac.jp
Fax: +81-3-5498-6391
Tel: +81-3-5498-6391

Abstract

Six cyanine dyes (including symmetric and unsymmetrical trimethine and pentamethine cyanines with substituted benzoxazolyl or benzothiazolyl groups), were synthesized and evaluated for their in vitro antiprotozoal activities against Plasmodium falciparum K1, Trypanosoma cruzi, T. brucei rhodesiense and Leishmania donovani. Several trimethine cyanines containing benzothiazolyl groups exhibited strong activities against P. falciparum and T. cruzi, whilst one symmetric pentamethine cyanine containing a fluorinated benzothiazolyl group was highly active against T. b. rhodesiense.

Graphical abstract: Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities

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Article information

DOI
https://doi.org/10.1039/C2MD20136D
Article type
Concise Article
Submitted
25 May 2012
Accepted
06 Sep 2012
First published
11 Sep 2012

Med. Chem. Commun., 2012,3, 1435-1442

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Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities

J. Ge, Q. Zhang, J. Lu, M. Kaiser, S. Wittlin, R. Brun and M. Ihara, Med. Chem. Commun., 2012, 3, 1435 DOI: 10.1039/C2MD20136D

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