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Issue 11, 2012
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Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities

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Abstract

Six cyanine dyes (including symmetric and unsymmetrical trimethine and pentamethine cyanines with substituted benzoxazolyl or benzothiazolyl groups), were synthesized and evaluated for their in vitro antiprotozoal activities against Plasmodium falciparum K1, Trypanosoma cruzi, T. brucei rhodesiense and Leishmania donovani. Several trimethine cyanines containing benzothiazolyl groups exhibited strong activities against P. falciparum and T. cruzi, whilst one symmetric pentamethine cyanine containing a fluorinated benzothiazolyl group was highly active against T. b. rhodesiense.

Graphical abstract: Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities

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Publication details

The article was received on 25 May 2012, accepted on 06 Sep 2012 and first published on 11 Sep 2012


Article type: Concise Article
DOI: 10.1039/C2MD20136D
Med. Chem. Commun., 2012,3, 1435-1442

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    Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities

    J. Ge, Q. Zhang, J. Lu, M. Kaiser, S. Wittlin, R. Brun and M. Ihara, Med. Chem. Commun., 2012, 3, 1435
    DOI: 10.1039/C2MD20136D

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